September 2014: The Neurophenols team will presenting at the BENEFIQ, an international forum on health ingredients, which will be held on September 24-25th 2014 in Québec City.

Juin 2014: Alexandre Dal-Pan, Post-doc researcher at INAF, has participated at ISANH Congress at Lisbonne, the june 5th 2014.

December 2013: Nutrineuro laboratory has participated at the last meeting of the Institute of Nutrition Aquitaine Québec (INAQ), the december 10th 2013, in Bordeaux.

October 2013: Julien Bensalem, ACTIV’INSIDE PhD student linked to NUTRINEURO laboratory, won a Young Investigator Award at the " 6th International Congress on Polyphenols and Health" (ICPH6), in Buenos Aires (Argentina), the october 19th 2013.

May 2013: The Neurophenols Project was awarded for the Prix Agrimip des Lycéens 2013. This award is given to honor collaborative projects between scientific, technological, industrial and organizational large groups and academic research, in France (Aquitaine, Bretagne, Pays de la Loire) and Canada (Québec).



The Neurophenols project brings together more than 30 professionals including 22 scientists and engineers focused on research. These scientists are grouped into different cells, each working on a specific part of the project.

On this page, the scientists will keep you posted on research progress.



  • In vivo study







ACTIV’INSIDE PhD student, linked to NUTRINEURO laboratory (Bordeaux, FR)



Lecturer at NUTRINEURO laboratory (Bordeaux, FR)


"Within Neurophenols project, NutriNeuro laboratory aims to study the effects of a supplementation with botanical extracts rich in polyphenols on the learning and memory functions of aged mice, and to better understand the neurobiological mechanisms underlying these effects.

The first objective is to highlight an age-related memory deficit during behavioral tests involving specific brain structures altered by aging such as the hippocampus. The second objective is to verify the efficacy of a nutritional supplementation with polyphenols to attenuate the effects of age on cognitive functions. Following behavioral analyses, mechanistic aspects will be explored and in particular the effect on brain plasticity via analysis of gene expression (RT-qPCR) and neurons functional activity (immunohistochemistry).

Our current results show that older mice exhibit a delay in learning in a spatial memory task which is restored by a diet rich in polyphenols. This supplementation has no effect on young animals. Moreover, the enriched diet seems to improve retention in young and aged mice.”







Frédéric CALON

Teacher-Researcher at INAF (Laval University, Québec City, CA)


Alexandre DAL-PAN

Post-Doc researcher at INAF (Laval University, Québec City, CA))


"Our goal is to document the beneficial effects of the extracts in aged mice and in Alzheimer’s disease mouse models.

Among the existing Alzheimer’s disease animal models, we use specifically the tritransgenic mice (3xTg-AD). These mice gradually develop cognitive deficit, amyloid plaques and neurofibrillary tangles, characteristics of the disease.

Although the genetic causes of the disease are compelling, it is not yet possible to modify the genes of an individual. However, environmental factors are editable. This is why we look at the effects of a supplementation with fruit extracts on the appearance of these symptoms."







Véronique LERAY

Teacher-Researcher at ONIRIS (Nantes, FR)


Patrick NGUYEN

Director of the Nutrition and Endocrinology unit at ONIRIS (Nantes, FR)


"Unit of nutrition and endocrinology has several years of experiences on nutritional modulation of metabolic and endocrine parameters in dogs.

We contribute in Neurophenols project by:

  • Determining the effectiveness of each component of a specific blend of fruit extracts on the body oxidative and inflammatory status. These could be enhanced by botanical polyphenols. The evaluation will be done by assaying plasma markers and gene expression.
  • Testing the final blend safety, by measuring markers of liver and kidney health in dogs receiving different amounts of the fruit extracts blend."